junctional adhesion molecule B; JAM-B; junctional adhesion molecule 2; JAM-2; vascular endothelial junction-associated molecule; VE-JAM; CD322 (JAM2, C21orf43, VEJAM, UNQ219/PRO245)

Function

• may play a role in the processes of lymphocyte homing to secondary lymphoid organs
• interacts with JAM3

Structure

• belongs to the immunoglobulin superfamily
• contains 1 Ig-like C2-type domain
• contains 1 Ig-like V-type domain

Compartment

• cell junction, tight junction
• cell membrane; single-pass type 1 membrane protein
• localized at tight junctions of both epithelial cells & endothelial cells (putative)

Expression

• highest expression in the heart, placenta, lung, foreskin & lymph node
• prominently expressed on high endothelial venules
• also present on the endothelium of other vessels
• localized to the intercellular boundaries of high endothelial cells

More general terms

• junctional adhesion molecule
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=58494
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:58494
• OMIM: https://mirror.omim.org/entry/606870
• UniProt: http://www.uniprot.org/uniprot/P57087.html