CD6; T-cell differentiation antigen CD6; T12; TP120

Function

• role in cell adhesion
• binds to CD166
• after T-cell activation, becomes hyperphosphorylated on Ser & Thr & phosphorylated on Tyr

Structure

• contains intrachain disulfide bond(s)
• contains 3 SRCR domains

Compartment

membrane

Alternative splicing

named isoforms=5

• CD6A, CD6B, CD6C, CD6D, CD6E

Expression

• thymocytes
  • immature thymocytes - low levels
  • mature thymocytes - high levels
• mature T-cells
• subset of B-cells known as B-1 cells
• some cells in the brain

More general terms

• CD antigen
• glycoprotein
• adhesion receptor

Database

• OMIM: https://mirror.omim.org/entry/186720
• UniProt: http://www.uniprot.org/uniprot/P30203.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=923