CD166 antigen; activated leukocyte cell adhesion molecule; CD166 (ALCAM, MEMD)

Function

• cell adhesion molecule that binds to CD6
• role in neurite extension by neurons via heterophilic & homophilic interactions
• may play a role in the binding of T- & B-cells to activated leukocytes, as well as in interactions between cells of the nervous system

Structure

• CD6 binding site in the N-terminal Ig-like domain
• contains 3 Ig-like C2-type domain (immunoglobulin-like)
• contains 2 Ig-like V-type domain (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• expressed in spleen, placenta, liver, & weakly in liver
• expressed by activated T-cells, B-cells, monocytes & thymic epithelial cells
• expressed by neurons in the brain
• restricted expression in tumor cell lines
• preferentially expressed in highly metastasizing melanoma cell lines

More general terms

• CD antigen
• glycoprotein
• membrane protein
• immunoglobulin superfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=214
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:214
• OMIM: https://mirror.omim.org/entry/601662
• UniProt: http://www.uniprot.org/uniprot/Q13740.html