macrophage scavenger receptor types 1 & 2; macrophage acetylated LDL receptor 1 & 2; scavenger receptor class A member 1 (CD204, MSR1, SCARA1)

Function

• endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL)
• binding of acetylated & oxidized cholesterol
• may also bind aggregates of LDL:heparin:fibronectin

Structure

• homotrimer
• contains 1 collagen-like domain
• contains 1 SRCR domain

Compartment

membrane

Alternative splicing

named isoforms=2 May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Pathology

• implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis

More general terms

• scavenger receptor
• CD antigen
• oligomerizing protein
• glycoprotein

Additional terms

• fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN)
• heparin
• high density lipoprotein (HDL, alpha-lipoprotein)
• low density lipoprotein (LDL, beta-lipoprotein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4481
• OMIM: https://mirror.omim.org/entry/153622
• UniProt: http://www.uniprot.org/uniprot/P21757.html