metalloreductase STEAP4; six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; tumor necrosis factor; alpha-induced protein 9 (STEAP4, STAMP2, TNFAIP9)

Function

• metalloreductase that has the ability to reduce both Fe+3 to Fe+2 & Cu+2 to Cu+
• uses NAD+ as acceptor

Cofactor: FAD (putative)

Structure

• belongs to the STEAP family
• contains 1 ferric oxidoreductase domain

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• highly expressed in placenta, lung, heart & prostate
• detected at lower levels in liver, skeletal muscle, pancreas, testis & small intestine
• up-regulated by androgens, including testosterone & dihydrotestosterone

More general terms

• metalloreductase STEAP
• flavoprotein
• oxidoreductase
• metalloprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q687X5.html