microtubule-associated serine/threonine protein kinase 4 (MAST4, KIAA0303)

Function

• presumptive serine/threonine protein kinase
• phosphorylated upon DNA damage, probably by ATM or ATR

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 PDZ domain (DHR domain)
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=5

Expression

• highly expressed in most normal human tissues
• not highly expressed in testis, small intestine, colon or peripheral blood leukocytes

More general terms

• flavoprotein
• serine/threonine kinase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=375449
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:375449
• UniProt: http://www.uniprot.org/uniprot/O15021.html