insulin-like peptide INSL5; insulin-like peptide 5 (INSL5)

Function

• role in gut contractility or thymic development ?
• activates RXFP4 with high potency
  • appears to be the endogenous ligand for RXFP4

Structure

• heterodimer of a B chain & an A chain linked by 2 disulfide bonds
• belongs to the insulin family

Compartment

secreted

Expression

• highly expressed in rectum
• lower expression in uterus & colon

More general terms

• protein precursor
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10022
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10022
• OMIM: https://mirror.omim.org/entry/606413
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Q6.html