relaxin-3 receptor 2; relaxin family peptide receptor 4; G-protein coupled receptor 100; GPCR142 (RXFP4, GPR100, RLN3R2)

Function

• receptor for relaxin-3, bradykinin & kallidin
• activity may be via Gi proteins as binding of ligand inhibits cAMP accumulation

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid & colon

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• relaxin-3; prorelaxin H3; insulin-like peptide INSL7; insulin-like peptide 7 [Contains: relaxin-3 B chain; relaxin-3 A chain] (RLN3, INSL7, RXN3, ZINS4, UNQ6188/PRO20213)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3394
• OMIM: https://mirror.omim.org/entry/609043
• UniProt: http://www.uniprot.org/uniprot/Q8TDU9.html