gastrin-releasing peptide; contains: neuromedin-C; GRP-10 (GRP)

Introduction

Mammalian equivalent of the amphibian tetradecapeptide bombesin.

Function

• GRP stimulates gastrin release & release of other gastrointestinal hormones
• operates as a negative feedback, regulating fear
  • establishes a causal relationship between GRP-receptor gene expression, long-term potentiation, & amygdala- dependent memory for fear (putative)

Structure

• belongs to the bombesin/neuromedin-B/ranatensin family

Compartment

secreted

Alternative splicing

named isoforms=3

More general terms

• tachykinin (neurokinin)
• peptide precursor

Additional terms

• gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor (GRPR)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2922
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2922
• OMIM: https://mirror.omim.org/entry/137260
• UniProt: http://www.uniprot.org/uniprot/P07492.html