Ca+2-binding & coiled-coil domain-containing protein 2 (nuclear domain 10 protein NDP52, nuclear domain 10 protein 52, nuclear dot protein 52, antigen nuclear dot 52 kD protein, CALCOCO2, NDP52)

Function

• may play a role in ruffle formation & actin cytoskeleton organization
  • seems to negatively regulate constitutive secretion
  • part of a complex consisting of CALCOCO2, TAX1BP1 & MYO6
  • interacts with GEMIN4

Compartment

• cytoplasm, perinuclear region, Golgi

Expression

• expressed in all tissues tested
• highest expression in skeletal muscle
• lowest expression in brain

More general terms

• cytoskeletal protein
• Ca+2 binding protein

Database

• OMIM: https://mirror.omim.org/entry/604587
• UniProt: http://www.uniprot.org/uniprot/Q13137.html