Chimeric POTE-actin protein (POTAC, POTEF)

Structure

• in the N-terminal section; belongs to the POTE family family contains 5 ANK repeats

Compartment

• cytoplasm, cell cortex
• colocalizes with actin filaments

Expression

• expressed in breast cancer cell lines (at protein level)

Genetics

• results from the insertion of a beta-actin fragment at the C-terminus in the POTE2 paralog gene leading the formation of a new functional chimeric protein
• this insertion occured before the divergence of the Old World monkeys & apes
• in the C-terminal section, belongs to the actin

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/A5A3E0.html