afadin- & alpha-actinin-binding protein (ADIP, afadin DIL domain-interacting protein, SSX2-interacting protein, SSX2IP, KIAA0923)

Function

• component of an adhesion system
• role in organization of homotypic, interneuronal & heterotypic cell-cell adherens junctions
• may connect nectin-afadin & E-cadherin-catenin system through alpha-actinin
• role in organization of actin cytoskeleton at adherens junctions through afadin & alpha-actinin
• interacts with SSX2 & SSX3, not with SSX1 & SSX4

Structure

• both the N-terminal (1-79) & C-terminal(304-614) regions are required for interaction with SSX2

Compartment

• cell junction, adherens junction, nucleus
• not found at cell-matrix adherens junctions

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in brain > kidney, testis, spinal cord,liver, heart, lung, skeletal muscle, ovary, fetal liver, fetal brain
• little to no expression in pancreas, spleen
• in brain, expressed in all regions, highest expression in amygdala
• expressed in fetal tissues, mainly in liver & brain

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608690
• UniProt: http://www.uniprot.org/uniprot/Q9Y2D8.html