trafficking kinesin-binding protein 2; GABA-A receptor-interacting factor 1; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein (TRAK2, ALS2CR3, GRIF1, KIAA0549)

Function

• may regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR
• interacts with GABA-A receptor & O-GlcNAc transferase
• interacts with HGS (putative)
• interacts with RHOT1/Miro-1 & RHOT2/Miro-2

Structure

• O-glycosylated (putative)
• contains 1 HAP1 N-terminal domain

Compartment

• cytoplasm (putative), early endosome

Expression

• widely expressed
• highest expression in heart

More general terms

• cytoskeletal protein

Additional terms

• amyotrophic lateral sclerosis (ALS); Lou Gerig's disease
• amyotrophic lateral sclerosis [ALS] 2 chromosomal region candidate gene

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=66008
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:66008
• OMIM: https://mirror.omim.org/entry/607334
• UniProt: http://www.uniprot.org/uniprot/O60296.html