mitochondrial Rho GTPase 2 (MIRO-2, hMiro-2, Ras homolog gene family member T2, RHOT2, ARHT2, C16orf39)

Function

• mitochondrial GTPase trafficking
• role in control of anterograde transport of mitochondria & their subcellular distribution (putative)
• interacts with the kinesin-binding proteins TRAK1/OIP106 & TRAK2/GRIF1, forming a link between mitochondria & the trafficking apparatus of microtubules

Structure

• belongs to the mitochondrial Rho GTPase family
• contains 2 EF-hand domains
• contains 2 Miro domains

Compartment

mitochondrion outer membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• highly expressed in heart, liver, skeletal muscle, kidney, pancreas

More general terms

• guanosine triphosphatase (GTPase)
• mitochondrial membrane protein
• Ca+2 binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IXI1.html