mitochondrial Rho GTPase 1 (MIRO-1, hMiro-1, Ras homolog gene family member T1, Rac-GTP-binding protein-like protein, RHOT1, ARHT1)

Function

• mitochondrial GTPase involved in mitochondrial trafficking
• probably involved in control of anterograde transport of mitochondria & their subcellular distribution
• interacts with the kinesin-binding proteins TRAK1/OIP106 & TRAK2/GRIF1, forming a link between mitochondria & the trafficking apparatus of microtubules

Structure

• belongs to the mitochondrial Rho GTPase family
• contains 2 EF-hand domains
• contains 2 Miro domains

Compartment

mitochondrial outer membrane

Alternative splicing

named isoforms=6

Expression

• ubiquitously expressed
• expressed at high level in heart & skeletal muscle

More general terms

• mitochondrial membrane protein
• Ca+2 binding protein
• guanosine triphosphatase (GTPase)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IXI2.html