A-kinase anchor protein 11; AKAP-11; A-kinase anchor protein 220 kD; AKAP 220; hAKAP220; protein kinase A-anchoring protein 11; PRKA11 (AKAP11, AKAP220, KIAA0629)

Function

• binds to protein kinase A type II regulatory subunits & anchors/targets them

Structure

• PKA-RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
• belongs to the AKAP110 family

Compartment

• cytoplasm, cytoskeleton, centrosome
• cytoplasmic in premeiotic pachytene spermatocytes & in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes & mature sperm

Expression

• expressed in heart, brain, lung, liver, kidney, testis & ovary
• weakly expressed in skeletal muscle, pancreas & spleen

More general terms

• A-kinase anchor protein
• cytoskeletal protein
• phosphoprotein

Additional terms

• protein kinase A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11215
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11215
• OMIM: https://mirror.omim.org/entry/604696
• UniProt: http://www.uniprot.org/uniprot/Q9UKA4.html