growth arrest-specific protein 2; GAS-2 (GAS2)

Function

• may play a role in apoptosis by acting as a cell death substrate for caspases
• cleaved during apoptosis; the cleaved form induces rearrangements of actin cytoskeleton & changes in the shape of the affected cells
• may be involved in the membrane ruffling process
• cleaved, during apoptosis, on a specific Asp by caspases
• phosphorylated on Ser during the G0-G1 transition phase (putative)
• component of the microfilament system

Structure

• belongs to the GAS2 family
• contains 1 CH (calponin-homology) domain
• contains 1 GAR domain

Compartment

• cytoplasm, cytoskeleton (putative)
• membrane; peripheral membrane protein (putative)
• colocalizes with actin fibers at the cell border & along stress fibers in growth-arrested fibroblasts
• mainly membrane-associated
• when hyperphosphorylated, accumulates at membrane ruffles

Expression

• ubiquitously expressed with highest levels in liver, lung, & kidney
• not found in spleen
• specifically expressed at growth arrest

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2620
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2620
• OMIM: https://mirror.omim.org/entry/602835
• UniProt: http://www.uniprot.org/uniprot/O43903.html