Damage-regulated autophagy modulator (DRAM, DRAM1)

Function

• lysosomal modulator of autophagy
• role in p53/TP53-mediated apoptosis
• activated by p53/TP53
• not involved in p73/TP73-mediated autophagy

Structure

belongs to the TMEM77 family

Compartment

lysosome membrane

Expression

• induced by p53/TP53 & p73/TP73

Pathology

• significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing

More general terms

• anti-oncoprotein (tumor suppressor protein)
• transmembrane 6 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N682.html