Krueppel-like factor 6; B-cell-derived protein 1; core promoter element-binding protein; GC-rich sites-binding factor GBF; proto-oncogene BCD1; suppressor of tumorigenicity 12 protein; transcription factor Zf9 (KLF6, BCD1, COPEB, CPBP, ST12)
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Function
- transcriptional activator (putative)
- binds a GC box motif
- could play a role in B-cell growth & development
Structure
- the acidic N-terminal part may favor interaction with the basic domain of transcription factors
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in placenta > spleen, thymus, prostate, testis, small intestine, colon > pancreas, lung, liver, heart, skeletal muscle
- also expressed in fetal brain, spleen & thymus
Pathology
- defects in KLF6 are a cause of
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q99612.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/KLF6ID44002ch10p15.html
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1316
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1316
- OMIM: https://mirror.omim.org/entry/176807
- OMIM: https://mirror.omim.org/entry/602053
- OMIM: https://mirror.omim.org/entry/613659
- UniProt: http://www.uniprot.org/uniprot/Q99612.html