transcription factor MafB; v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB, KRML)

Function

• plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells (putative)
• interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); interaction attenuates MAFB activity

Structure

• leucine-zipper domain is involved in the interaction with LRPICD
• belongs to the bZIP family, Maf subfamily
• contains 1 bZIP domain

Compartment

nucleus (putative)

More general terms

• maf family protein
• proto oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9935
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Q3.html