SAFB-like transcription modulator (modulator of estrogen-induced transcription, SLTM, MET)

Function

• when overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 1 RRM (RNA recognition motif) domain
• contains 1 SAP domain

Compartment

• nucleus
• detected in punctate structures (putative)

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• phosphoprotein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NWH9.html