spermatid perinuclear RNA-binding protein (STRBP, SPNR)

Function

• role in spermatogenesis & sperm function
• role in regulation of cell growth
• binds to double-stranded DNA & RNA
• binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA
• binds also to single-stranded poly(G) RNA
• binds non-specifically to mRNA PRM1 3'-UTR & adenovirus VA RNA
• interacts with EIF2AK2
• associates with microtubules

Structure

• contains 2 DRBM domains (double-stranded RNA-binding domains)
• contains 1 DZF domain

Compartment

• cytoplasm
• microtubule-associated, localizes to the manchette in developing spermatids

Alternative splicing

named isoforms=2

More general terms

• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96SI9.html