sperm protamine-P1; Cysteine-rich protamine (PRM1)

Function

• protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis
• they compact sperm DNA into a highly condensed, stable & inactive complex
• cross-linked by interchain disulfide bonds around the DNA-helix

Structure

belongs to the protamine-P1 family

Compartment

nucleus

Expression

testis

More general terms

• protamine

Database

• UniProt: http://www.uniprot.org/uniprot/P04553.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5619
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5619
• OMIM: https://mirror.omim.org/entry/182880