cleavage & polyadenylation specificity factor 6 (cleavage & polyadenylation specificity factor 68 kD subunit, CPSF 68 kD subunit, pre-mRNA cleavage factor Im 68-kD subunit, protein HPBRII-4/7, CPSF6, CFIM68)

Function

• component of the cleavage factor Im complex (CFIm)
• pre-MRNA 3'-end poly(A) site cleavage & poly(A) addition in association with CPSF5
• binds to cleavage & polyadenylation RNA substrates
• interacts CPSF5, SFRS3, SFRS7, SFRS10, SNRP70

Compartment

• nucleus
• in punctate subnuclear structures localized adjacent to nuclear speckles (paraspeckles)

Alternative splicing

named isoforms=3

More general terms

• protein subunit
• nuclear protein
• RNA-binding protein
• phosphoprotein

Component of

• pre-mRNA cleavage factor Im complex

Database

• OMIM: https://mirror.omim.org/entry/604979
• UniProt: http://www.uniprot.org/uniprot/Q16630.html