programmed cell death protein 4; nuclear antigen H731-like; neoplastic transformation inhibitor protein; protein 197/15a (PDCD4, H731)

Function

• tumor suppressor protein
• inhibits tumor promoter-induced neoplastic transformation
• down-regulates expression of MAP4K1 inhibiting MAPK85 activation & consequent JUN-dependent transcription
• role in apoptosis (putative)
• inhibits helicase activity of EIF4A & cap-dependent translation
• binds RNA
• interacts with EIF4A1 & EIF4A2
  • binds EIF4A1 via the MA3 domains

Structure

• belongs to the PDCD4 family
• contains 2 MA3 domains

Compartment

• nucleus, cytoplasm
• shuttles between the nucleus & cytoplasm
• predominantly nuclear under normal growth conditions
• exported from the nucleus in the absence of serum

Expression

• up-regulated in proliferative cells
• highly expressed in epithelial cells of the mammary gland
• IL2 stimulation inhibits expression
• IL12 increases expressio

Pathology

• loss of expression correlated with tumor progression of lung cancer & colon carcinoma

More general terms

• nuclear protein
• RNA-binding protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608610
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27250
• UniProt: http://www.uniprot.org/uniprot/Q53EL6.html