organic solute transporter subunit beta; OST-beta (OSTB, SLC51B)
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Function
Structure
belongs to the OST-beta family
Compartment
- cell membrane
- mainly restricted to the lateral & basal membranes of ileal enterocytes
Expression
- widely expressed with a high expression in ileum
- expressed in testis, colon, liver, small intestine, kidney, ovary & adrenal gland; & at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland & fat
- positively regulated via the bile acid-activated nuclear receptor farnesoid X receptor (NR1H4/FXR)