organic solute transporter subunit alpha; OST-alpha (OSTA; SLC51A)

Function

• component of the ost-alpha/ost-beta complex
• interacts with OSTB

Structure

belongs to the OST-alpha family

Compartment

• cell membrane
  • mainly restricted to the lateral & basal membranes of ileal enterocytes

Expression

• widely expressed with a high expression in ileum
• expressed in testis, colon, liver, small intestine, kidney, ovary & adrenal gland; & at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland & fat
• positively regulated via the bile acid-activated nuclear receptor farnesoid X receptor (NR1H4/FXR) in adrenal, kidney & intestine

More general terms

• protein subunit
• membrane protein

Component of

• ost-alpha/ost-beta complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UW1.html