immunoglobulin superfamily member 6 (protein DORA, IGSF6, DORA)

Structure

• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

membrane

Expression

• expressed in peripheral blood lymphocytes, spleen & lymph node, > thymus, bone marrow & fetal liver
• no expression in non-immune tissues
• induced by TNF-alpha & GM-CSF/CSF2 in dendritic cells
• down regulation by PMA & ionomycin in monocytes Misc:
• gene localized region associated with inflammatory bowel disease
• coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA

More general terms

• membrane protein
• immunoglobulin superfamily protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1026
• OMIM: https://mirror.omim.org/entry/606222
• UniProt: http://www.uniprot.org/uniprot/O95976.html