N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 (NGalNAc-T1, beta-1,4-N-acetylgalactosaminyltransferase 4, Beta4GalNAc-T4, Beta4GalNAcT4, B4GALNT4)

Function

• transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans & probably O-linked glycans

UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group <--> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl group

Structure

• belongs to the chondroitin N-acetylgalactosaminyltransferase family

Compartment

Golgi stack membrane

Expression

• highly expressed in ovary, adult & fetal brain
• also expressed in fetal kidney & lung

More general terms

• beta-1,4-N-acetylgalactosaminyltransferase (B4GALNT)
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q76KP1.html