chondroitin sulfate synthase 2; chondroitin glucuronyltransferase 2; chondroitin-polymerizing factor; ChPF; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II; N-acetylgalactosaminyltransferase 2 (CHPF, CSS2, UNQ651/PRO1281)

Function

• both beta-1,3-glucuronic acid & beta-1,4-N-acetyl galactosamine transferase activity
• transfers GlcUA from UDP-GlcUA & GalNAc UDP-GalNAc non-reducing end of elongating chondroitin polymer
• activity is much reduced compared to CHSY1
• binds CHSY1

Cofactor:

• divalent cations
• highest activities with Mn+2
• can also utilize Co+2

Structure

• belongs to the chondroitin N-acetylgalactosaminyltransferase family

Compartment

Golgi

Expression

• ubiquitous
• highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, small intestine, placenta

More general terms

• chondroitin sulfate synthase
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79586
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79586
• OMIM: https://mirror.omim.org/entry/610405
• UniProt: http://www.uniprot.org/uniprot/Q8IZ52.html