protein disulfide-isomerase TXNDC10 (thioredoxin domain-containing protein 10, thioredoxin-related transmembrane protein 3, TXNDC10, KIAA1830, TMX3)

Function

• probable disulfide isomerase
• role in folding of proteins containing disulfide bonds
• may act as a dithiol oxidase
• catalyzes rearrangement of -S-S- bonds in proteins

Redox potential: E(0) is -157 mV

Structure

• belongs to the protein disulfide isomerase family
• contains 1 thioredoxin domain
• di-lysine motif confers endoplasmic reticulum localization for type 1 membrane proteins
• N-glycosylated

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye, muscle
• not up-regulated by unfolded protein response

More general terms

• protein disulfide isomerase
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96JJ7.html