lipase member H (membrane-associated phosphatidic acid-selective phospholipase A1-alpha, mPA-PLA1 alpha, LPD lipase-related protein, phospholipase A1 member B, LIPH, LPDLR, MPAPLA1, PLA1B)

Function

• hydrolyzes specifically phosphatidic acid produce lysophosphatidic acid
• inhibited by sodium vanadate

Structure

• belongs to the AB hydrolase superfamily, Lipase family

Compartment

• secreted, membrane, peripheral membrane

Expression

• present in intestine
• expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung & pancreas
• expressed at lower level in brain, spleen & heart
• in hair, it is prominently expressed in hair follicles, including stem cell-rich bulge region

Pathology

• defects in LIPH are the cause of alopecia universalis congenita Mari type

More general terms

• lipase
• secreted protein
• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/604379
• OMIM: https://mirror.omim.org/entry/607365
• UniProt: http://www.uniprot.org/uniprot/Q8WWY8.html