podocalyxin-like protein 2 (endoglycan, PODXL2)

Function

• binds to SELL/L-selectin

Structure

• belongs to the podocalyxin family
• homodimer. disulfide-linked
• glycosylated, contains chondroitin sulfate
• displays sialylated O-linked oligosaccharides
• sulfation & sialylated O-linked oligosaccharides are necessary for SELL/L-selectin binding

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in brain > pancreas, kidney & lymphoid node > liver
• detected in both endothelial cells & CD34+ bone marrow cells

More general terms

• glycoprotein
• membrane protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NZ53.html