Chemokine-like factor (C32, CKLF, CKLF1, HSPC224, UNQ410/PRO772)

Function

• role in inflammation & regeneration of skeletal muscle
• partly inhibited by interleukin 10
• isoform CKLF1 has chemotactic response in rat monocytes, neutrophils, & lymphocytes

Structure

• belongs to the chemokine-like factor family
• contains 1 MARVEL domain

Compartment

• isoform CKLF1 secreted
• isoforms CKLF2, CKLF4 membrane

Expression

• all 4 isoforms have highest expression levels in adult spleen, lungs, testis, ovary, peripheral blood leucocyte, placenta, pancreas, & in fetal brain, skeletal muscle, thymus & heart
• lower expression levels in adult skeletal muscle, liver, thymus, colon, prostate, & fetal spleen & liver

More general terms

• secreted protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UBR5.html