ribosome-attached membrane protein 4 (stress-associated endoplasmic reticulum protein 1, RAMP4, SERP1)

Function

• interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum (ER)
• protects unfolded target proteins against degradation during ER stress
• may facilitate glycosylation of target proteins after termination of ER stress
• may modulate the use of N-glycosylation sites on target proteins
• interacts with SEC61B, SEC61A1 & the SEC61 complex
• interacts with CANX (putative)

Structure

belongs to the RAMP4 family

Compartment

• membrane
• endoplasmic reticulum membrane, cytoplasmic side (putative)

More general terms

• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y6X1.html