leucine-rich repeat-containing protein 33; negative regulator of reactive oxygen species (LRRC33 NRROS UNQ3030/PRO9833)

Function

• may play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation & cytokine production
• interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 & probably other Toll-like receptors

Structure

contains 21 LRR repeats (leucine-rich repeats)

Compartment

• cell membrane
• single-pass type 1 membrane protein

Expression

• ubiquitous,
• high level of expression found in bone marrow, thymus, liver, lung, intestine & spleen

More general terms

• leucine-rich repeat-containing protein (LRRC)
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=375387
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:375387
• OMIM: https://mirror.omim.org/entry/615322
• UniProt: http://www.uniprot.org/uniprot/Q86YC3.html