stromal membrane-associated protein 1 (SMAP1)

Function

• GTPase activating protein that acts on ARF6
• role in clathrin-dependent endocytosis
• role in erythropoiesis (putative)
• interacts with ARF6
• interacts with clathrin heavy chains via the clathrin box-like motif

Structure

contains 1 Arf-GAP domain

Compartment

cell membrane, cytoplasmic

Alternative splicing

named isoforms=3

Expression

• expressed in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid, stomach

More general terms

• ADP-ribosylation factor GTPase activating protein (ARF-GAP)
• membrane protein
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IYB5.html