brother of CDO (protein BOC, BOC)

Function

• component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells
• promotes differentiation of myogenic cells
• part of a complex that contains BOC, CDON, NEO1, cadherins & CTNNB1
• interacts with NTN3
• interacts with CDH2 & CTNNB1
• interacts with CDH15 only during the early stages of myoblast differentiation

Structure

• N-glycosylated
• C-terminal cytoplasmic domain is not required for stimulation of myogenesis
• contains 3 fibronectin F3 modules
• contains 4 Ig-like C2-type domains (immunoglobulin-like)

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• expressed in skeletal muscle, heart, thymus, kidney & small intestine > brain, placenta, lung & colon mucosa

More general terms

• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/608708
• UniProt: http://www.uniprot.org/uniprot/Q9BWV1.html