cell adhesion molecule-related/down-regulated by oncogenes (CDON, CDO)

Function

• component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells
• promotes differentiation of myogenic cells
• component of complex containing BOC, CDON, NEO1, cadherins, CTNNB1
• interacts with NTN3
• interacts with GAS1

Structure

• N-glycosylated
• contains 3 fibronectin F3 domains
• contains 5 Ig-like C2-type domains

Compartment

membrane

Alternative splicing

named isoforms=2

Pathology

• defects in CDON are the cause of holoprosencephaly type 11

More general terms

• adhesion receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50937
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50937
• OMIM: https://mirror.omim.org/entry/608707
• OMIM: https://mirror.omim.org/entry/614226
• UniProt: http://www.uniprot.org/uniprot/Q4KMG0.html