Neogenin; immunoglobulin superfamily DCC subclass member 2 (NEO1 IGDCC2 NGN)

Function

• may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state
• may also function as a cell adhesion molecule in a broad spectrum of embryonic & adult tissues interacts with RGMA

Structure

• belongs to the immunoglobulin superfamily, DCC family
• contains 6 fibronectin F3 modules
• contains 4 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• cell membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Expression

• widely expressed & also in cancer cell lines

More general terms

• immunoglobulin superfamily protein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4756
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4756
• OMIM: https://mirror.omim.org/entry/601907
• UniProt: http://www.uniprot.org/uniprot/Q92859.html