neuropilin & tolloid-like protein 2; brain-specific transmembrane protein containing 2 CUB & 1 LDL-receptor class A domains protein 2 (NETO2, BTCL2, UNQ1926/PRO4401)

Function

• accessory subunit of neuronal kainate receptors, GRIK2 & GRIK3
• increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, & increasing the open probability of the receptor channels
• modulates the agonist sensitivity of kainate receptors
• slows the decay of kainate receptor-mediated excitatory postsynaptic currents, thus directly influencing synaptic transmission
• interacts with GRIK2 & GRIK3
• does not interact with AMPA receptors or with NMDA receptors

Structure

• N-glycosylated (putative)
• contains 2 CUB domains
• contains 1 LDL-receptor class A domain

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=2

More general terms

• membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81831
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81831
• OMIM: https://mirror.omim.org/entry/607974
• UniProt: http://www.uniprot.org/uniprot/Q8NC67.html