glutamate receptor, ionotropic kainate 3; glutamate receptor 7; GluR-7; GluR7; excitatory amino acid receptor 5; EAA5 (GRIK3, GLUR7)

Function

• postsynaptic receptor for excitatory neurotransmitter L-glutamate in the central nervous system
• receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA
• interacts with PRKCABP

Structure

• homomeric
• can also coassemble with either GRIK4 or GRIK5 to form heteromeric receptors
• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane
• cell junction, synapse, postsynaptic cell membrane

Genetics

• RNA editing:
  • modified positions=352, partially edited

More general terms

• glutamate receptor beta
• glycoprotein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/138243
• UniProt: http://www.uniprot.org/uniprot/Q13003.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2899