glutamate receptor, ionotropic kainate 5; glutamate receptor KA-2; KA2; excitatory amino acid receptor 2; EAA2 (GRIK5)

Function

• postsynaptic receptor for excitatory neurotransmitter L-glutamate in the central nervous system
• receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD
• associates with GRIK1 (both edited & unedited versions), GRIK2, or GRIK3 to form functional channels
• homomeric associations do not produce any channel activity (putative)

Structure

• belongs to the glutamate-gated ion channel (TC 1.A.10) family

Compartment

• cell membrane
• cell junction, synapse, postsynaptic cell membrane

More general terms

• glycoprotein
• receptor
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2901
• OMIM: https://mirror.omim.org/entry/600283
• UniProt: http://www.uniprot.org/uniprot/Q16478.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2901