glutamate receptor, ionotropic kainate 2; glutamate receptor 6; GluR-6; GluR6; excitatory amino acid receptor 4; EAA4 (GRIK2, GLUR6)

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Function

Structure

Compartment

Alternative splicing

named isoforms=5

Expression

Pathology

Genetics

  • RNA editing
    • modified positions=567, 571, 621
    • partially edited
    • the presence of Gln at position 621 (non-edited) determines channels with low Ca+2 permeability, whereas Arg (edited) determines a higher Ca+2 permeability especially if the preceding sites are fully edited
    • receptor is nearly completely edited in all gray matter structures (90% of the receptors), whereas much less edited in the white matter (10% of the receptors)

More general terms

References

Database