GTPase IMAP family member 5; immunity-associated nucleotide 4-like 1 protein; immunity-associated nucleotide 5 protein; IAN-5; hIAN5; immunity-associated protein 3 (GIMAP5, IAN4L1, IAN5, IMAP3)

Function

• required for mitochondrial integrity & T-cell survival
• may contribute to T-cell quiescence (putative)

Structure

belongs to the IAN GTP-binding protein family

Compartment

• mitochondrial outer membrane
• lysosome
• type IV membrane protein

Alternative splicing

named isoforms=2

Expression

• widely expressed with high levels in lymph nodes & spleen
• high expression found in CD4 & CD8-positive T-cells & monocytes
• very low levels in B-lymphocytes

Pathology

• highly expressed in B-lymphocyte-derived neoplasms

More general terms

• membrane protein
• GTPase, IMAP family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55340
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55340
• OMIM: https://mirror.omim.org/entry/608086
• UniProt: http://www.uniprot.org/uniprot/Q96F15.html