MAM domain-containing glycosylphosphatidylinositol anchor protein 1; GPI & MAM protein; GPIM; glycosylphosphatidylinositol-MAM; MAM domain-containing protein 3 (MDGA1, MAMDC3)

Function

• required for radial migration of cortical neurons in the superficial layer of the neocortex (putative)
• interacts heterophilically through its MAM domain with proteins in axon-rich regions & through its Ig-like domains with proteins in differentiating muscle (putative)

Structure

• contains 1 fibronectin F3 module
• contains 6 Ig-like (immunoglobulin-like) domains
• contains 1 MAM domain

Compartment

• cell membrane; lipid-anchor, GPI-anchor
• associated with lipid rafts

Alternative splicing

named isoforms=2

Expression

• expressed in brain, heart, skeletal muscle & kidney
• overexpressed in tumor tissues

More general terms

• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=266727
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:266727
• OMIM: https://mirror.omim.org/entry/609626
• UniProt: http://www.uniprot.org/uniprot/Q8NFP4.html