ectonucleoside triphosphate diphosphohydrolase 6; NTPDase 6; CD39 antigen-like 2 (ENTPD6, CD39L2, IL6ST2)

Function

• might support glycosylation reactions in the Golgi
• when released from cells, might catalyze hydrolysis of extracellular nucleotides
• hydrolyzes preferentially nucleoside 5'-diphosphates,
• nucleoside 5'-triphosphates are hydrolyzed only to a minor extent
• no hydrolysis of nucleoside 5'-monophosphates
• the order of activity with different substrates is: GDP > IDP >> UDP = CDP >> ADP (putative)

Cofactor: Ca+2 (putative), Mg+2 (putative)

Structure

belongs to the GDA1/CD39 NTPase family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein
• secreted, occurs in a soluble extracellular form

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues, but predominantly in heart

More general terms

• CD39 like protein
• membrane protein
• phosphoprotein

Additional terms

• CD39; ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ecto-ATP diphosphohydrolase; ATPDase; lymphoid cell activation antigen; ecto-apyrase (ENTPD1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=955
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:955
• OMIM: https://mirror.omim.org/entry/603160
• UniProt: http://www.uniprot.org/uniprot/O75354.html