galactose-3-O-sulfotransferase 4; gal3ST-4; beta-galactose-3-O-sulfotransferase 4; gal-beta-1,3-galNAc 3'-sulfotransferase (GAL3ST4)

Function

• catalyzes transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins
• good substrates include asialofetuin, gal-beta-1,3-galNAc & gal-beta-1,3 (GlcNAc-beta-1,6)galNAc
• protein modification; carbohydrate sulfation

Cofactor: Mn+2

Kinetic parameters:

• pH dependence: optimum pH is 6-7

Structure

• belongs to the galactose-3-O-sulfotransferase family

Compartment

• Golgi, Golgi stack membrane
• single-pass type 2 membrane protein (probable)

Expression

• expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea & adrenal gland
• expressed at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid & lymph node

More general terms

• sulfotransferase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79690
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79690
• OMIM: https://mirror.omim.org/entry/608235
• UniProt: http://www.uniprot.org/uniprot/Q96RP7.html