Kunitz-type protease inhibitor 2; hepatocyte growth factor activator inhibitor type 2; HAI-2; placental bikunin (SPINT2, HAI2, KOP)

Function

• inhibitor of HGF activator
• also inhibits plasmin, plasma kallikrein & tissue kallikrein, & factor XIa

Structure

• contains 2 BPTI/Kunitz inhibitor domains

Compartment

• membrane
• single-pass type 1 membrane protein (putative)

Expression

• expressed in placenta, kidney, pancreas, prostate, testis, thymus, & trachea

Pathology

• defects in SPINT2 are the cause of hereditary diarrhea type 3

More general terms

• Kunitz type serine protease inhibitor
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10653
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10653
• OMIM: https://mirror.omim.org/entry/270420
• OMIM: https://mirror.omim.org/entry/605124
• UniProt: http://www.uniprot.org/uniprot/O43291.html