Leukocyte-specific transcript 1 protein; protein B144 (LST1 B144)

Function

• possible role in modulating immune responses
• isoforms 1 & 2 have an inhibitory effect on lymphocyte proliferation
• induces morphological changes including production of filopodia & microspikes when overexpressed in a variety of cell types
• may be involved in dendritic cell maturation

Structure

belongs to the LST1 family

Compartment

• membrane, Golgi membrane
• intracytoplasmic membrane
• detected in a perinuclear region corresponding to the localization of the Golgi apparatus & throughout the cytoplasm

Alternative splicing

named isoforms=9 additional isoforms seem to exist

Expression

• expressed in B-cells & macrophages
• expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver & brain
• expression induced by interferon gamma

More general terms

• membrane protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7940
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7940
• OMIM: https://mirror.omim.org/entry/109170
• UniProt: http://www.uniprot.org/uniprot/O00453.html